CACNG4

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.^[5][6]

AliasesCACNG4, calcium voltage-gated channel auxiliary subunit gamma 4

External IDsOMIM: 606404; MGI: 1859167; HomoloGene: 8674; GeneCards: CACNG4; OMA:CACNG4 - orthologs

Chr.Chromosome 17 (human)^[1]

End67,033,398 bp^[1]

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CACNG4
Identifiers
Aliases	CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
External IDs	OMIM: 606404; MGI: 1859167; HomoloGene: 8674; GeneCards: CACNG4; OMA:CACNG4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 66,964,707 bp[1] End 67,033,398 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 107,623,183 bp[2] End 107,685,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence nucleus accumbens putamen caudate nucleus amygdala hypothalamus entorhinal cortex endothelial cell dorsal motor nucleus of vagus nerve Top expressed in Rostral migratory stream otic placode otic vesicle nucleus of stria terminalis saccule habenula neural layer of retina nucleus accumbens lumbar subsegment of spinal cord ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity channel regulator activity calcium channel activity voltage-gated calcium channel activity calcium channel regulator activity ionotropic glutamate receptor binding Cellular component endocytic vesicle membrane plasma membrane membrane voltage-gated calcium channel complex integral component of membrane integral component of plasma membrane AMPA glutamate receptor complex somatodendritic compartment cell surface postsynaptic density cell body postsynaptic density membrane L-type voltage-gated calcium channel complex glutamatergic synapse integral component of postsynaptic density membrane Biological process regulation of AMPA receptor activity regulation of ion transmembrane transport calcium ion transport ion transport transmission of nerve impulse membrane depolarization calcium ion transmembrane transport response to cocaine positive regulation of AMPA receptor activity regulation of postsynaptic neurotransmitter receptor activity positive regulation of synaptic transmission, glutamatergic neurotransmitter receptor transport, postsynaptic endosome to lysosome postsynaptic neurotransmitter receptor diffusion trapping neurotransmitter receptor internalization cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27092 54377 Ensembl ENSG00000075461 ENSMUSG00000020723 UniProt Q9UBN1 Q9JJV4 RefSeq (mRNA) NM_014405 NM_019431 RefSeq (protein) NP_055220 NP_062304 Location (UCSC) Chr 17: 66.96 – 67.03 Mb Chr 11: 107.62 – 107.69 Mb PubMed search [3] [4]
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L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.^[6]