Calumenin

Calumenin is a protein that in humans is encoded by the CALU gene.^[5][6]

AliasesCALU, calumenin

External IDsOMIM: 603420; MGI: 1097158; HomoloGene: 936; GeneCards: CALU; OMA:CALU - orthologs

Chr.Chromosome 7 (human)^[1]

End128,773,400 bp^[1]

Quick facts CALU, Identifiers ...

CALU
Identifiers
Aliases	CALU, calumenin
External IDs	OMIM: 603420; MGI: 1097158; HomoloGene: 936; GeneCards: CALU; OMA:CALU - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 128,739,292 bp[1] End 128,773,400 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 29,348,068 bp[2] End 29,377,109 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium smooth muscle tissue tendon of biceps brachii thoracic aorta ascending aorta right coronary artery Achilles tendon Descending thoracic aorta left coronary artery popliteal artery Top expressed in gastrula calvaria dermis efferent ductule molar stroma of bone marrow umbilical cord body of femur atrium Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding protein binding Cellular component Golgi apparatus endoplasmic reticulum membrane membrane melanosome sarcoplasmic reticulum extracellular region endoplasmic reticulum sarcoplasmic reticulum lumen endoplasmic reticulum lumen Biological process post-translational protein modification biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 813 12321 Ensembl ENSG00000128595 ENSMUSG00000029767 UniProt O43852 O35887 RefSeq (mRNA) NM_001130674 NM_001199671 NM_001199672 NM_001199673 NM_001199674 NM_001219 NM_001285412 NM_007594 NM_184053 RefSeq (protein) NP_001124146 NP_001186600 NP_001186601 NP_001186602 NP_001210 NP_001272341 NP_031620 NP_908942 Location (UCSC) Chr 7: 128.74 – 128.77 Mb Chr 6: 29.35 – 29.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.^[6]