CAMKK1

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.^[5][6]

AliasesCAMKK1, CAMKKA, calcium/calmodulin-dependent protein kinase kinase 1, calcium/calmodulin dependent protein kinase kinase 1

External IDsOMIM: 611411; MGI: 1891766; HomoloGene: 10327; GeneCards: CAMKK1; OMA:CAMKK1 - orthologs

Chr.Chromosome 17 (human)^[1]

End3,894,891 bp^[1]

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CAMKK1
Identifiers
Aliases	CAMKK1, CAMKKA, calcium/calmodulin-dependent protein kinase kinase 1, calcium/calmodulin dependent protein kinase kinase 1
External IDs	OMIM: 611411; MGI: 1891766; HomoloGene: 10327; GeneCards: CAMKK1; OMA:CAMKK1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,860,315 bp[1] End 3,894,891 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,909,834 bp[2] End 72,932,899 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe pancreatic ductal cell Brodmann area 9 prefrontal cortex right hemisphere of cerebellum middle temporal gyrus primary visual cortex endothelial cell cingulate gyrus anterior cingulate cortex Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus hippocampus proper facial motor nucleus anterior horn of spinal cord central gray substance of midbrain lumbar subsegment of spinal cord primary motor cortex cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding calmodulin-dependent protein kinase activity calmodulin binding Cellular component cytosol nucleus cytoplasm nucleoplasm Biological process protein phosphorylation phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction positive regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84254 55984 Ensembl ENSG00000004660 ENSMUSG00000020785 UniProt Q8N5S9 Q8VBY2 RefSeq (mRNA) NM_032294 NM_172206 NM_172207 NM_018883 NM_001362841 RefSeq (protein) NP_115670 NP_757343 NP_757344 NP_061371 NP_001349770 Location (UCSC) Chr 17: 3.86 – 3.89 Mb Chr 11: 72.91 – 72.93 Mb PubMed search [3] [4]
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The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase (CAMK) subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.^[6]