CASC3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Protein CASC3 is a protein that in humans is encoded by the CASC3 gene.[5][6][7]
AliasesCASC3, BTZ, MLN51, cancer susceptibility candidate 3, cancer susceptibility 3, exon junction complex subunit, CASC3 exon junction complex subunit
External IDsOMIM: 606504; MGI: 2179723; HomoloGene: 7208; GeneCards: CASC3; OMA:CASC3 - orthologs
Function
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.[7]
