CASP8AP2

CASP8AP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LR8
Identifiers
Aliases	CASP8AP2, CED-4, FLASH, RIP25, caspase 8 associated protein 2
External IDs	OMIM: 606880; MGI: 1349399; HomoloGene: 8066; GeneCards: CASP8AP2; OMA:CASP8AP2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	89,874,436 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	32,653,265 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; epithelium of colon; ; testicle; ; ventricular zone; ; ganglionic eminence; ; tonsil; ; gonad; ; endometrium; ; lymph node;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; genital tubercle; ; tail of embryo; ; cumulus cell; ; primitive streak; ; abdominal wall; ; Gonadal ridge; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activator activity involved in apoptotic process; DNA binding; death receptor binding; transcription corepressor activity; SUMO polymer binding; protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process;
Cellular component	cytoplasm; PML body; mitochondrion; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; Fas signaling pathway; transcription, DNA-templated; cellular response to mechanical stimulus; apoptotic signaling pathway; cell cycle; activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; apoptotic process; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	9994
	26885
	ENSG00000118412; ENSG00000288475
	ENSMUSG00000028282
	Q9UKL3
	Q9WUF3
	NM_012115; NM_001137667; NM_001137668
	NM_001122978; NM_011997
	NP_001131139; NP_001131140; NP_036247
	NP_001116450; NP_036127
	Wikidata
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