CBR3

CBR3
Identifiers
Aliases	CBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs	OMIM: 603608; MGI: 1309992; GeneCards: CBR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HRB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,146,562 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,487,878 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; tendon of biceps brachii; ; olfactory zone of nasal mucosa; ; parotid gland; ; cartilage tissue; ; minor salivary glands; ; vulva; ; oral cavity; ; mucosa of pharynx; ; Achilles tendon;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; mucous cell of stomach; ; cervix; ; esophagus; ; stroma of bone marrow; ; skin of external ear; ; ankle joint; ; lip; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NADPH binding; carbonyl reductase (NADPH) activity; 3-keto sterol reductase activity; protein binding;
Cellular component	nucleoplasm; extracellular space; cytoplasm; cytosol;
Biological process	phylloquinone catabolic process; cognition; xenobiotic metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	874
	109857
	ENSG00000159231
	ENSMUSG00000022947
	O75828
	Q8K354
	NM_001236
	NM_173047
	NP_001227
	NP_766635
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.^[5]^[6]^[7] The enzyme is a member of short chain dehydrogenase/reductase superfamily (SDR).

AliasesCBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3

PDBOrtholog search: PDBe RCSB

Quick facts Identifiers, Aliases ...

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Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.^[7]

See also