CCRL1

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.^[5][6]

AliasesACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1, atypical chemokine receptor 4

External IDsOMIM: 606065; MGI: 2181676; HomoloGene: 49474; GeneCards: ACKR4; OMA:ACKR4 - orthologs

Chr.Chromosome 3 (human)^[1]

End132,618,967 bp^[1]

Quick facts ACKR4, Identifiers ...

ACKR4
Identifiers
Aliases	ACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1, atypical chemokine receptor 4
External IDs	OMIM: 606065; MGI: 2181676; HomoloGene: 49474; GeneCards: ACKR4; OMA:ACKR4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1 Start 132,597,270 bp[1] End 132,618,967 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 103,961,356 bp[2] End 104,004,132 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum ascending aorta gallbladder Descending thoracic aorta subcutaneous adipose tissue right coronary artery skin of leg Achilles tendon skin of abdomen pituitary gland Top expressed in lip morula choroid plexus of fourth ventricle body of femur umbilical cord esophagus calvaria thymus stroma of bone marrow zone of skin More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity chemokine binding scavenger receptor activity G protein-coupled receptor activity protein binding chemokine receptor activity C-C chemokine receptor activity C-C chemokine binding Cellular component recycling endosome plasma membrane membrane endosome integral component of membrane early endosome integral component of plasma membrane external side of plasma membrane Biological process receptor-mediated endocytosis signal transduction immune response chemotaxis G protein-coupled receptor signaling pathway chemokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51554 252837 Ensembl ENSG00000129048 ENSMUSG00000079355 UniProt Q9NPB9 Q924I3 RefSeq (mRNA) NM_178445 NM_016557 NM_145700 RefSeq (protein) NP_057641 NP_848540 NP_663746 Location (UCSC) Chr 3: 132.6 – 132.62 Mb Chr 9: 103.96 – 104 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.^[6]