CCT2 (gene)

From Wikipedia, the free encyclopedia

AliasesCCT2, 99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta, chaperonin containing TCP1 subunit 2
End69,601,570 bp[1]
CCT2
Identifiers
AliasesCCT2, 99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta, chaperonin containing TCP1 subunit 2
External IDsOMIM: 605139; MGI: 107186; HomoloGene: 4696; GeneCards: CCT2; OMA:CCT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006431
NM_001198842

NM_007636
NM_001358767

RefSeq (protein)

NP_001185771
NP_006422

NP_031662
NP_001345696

Location (UCSC)Chr 12: 69.59 – 69.6 MbChr 10: 116.89 – 116.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene.[5][6]

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.[6]

Interactions

CCT2 (gene) has been shown to interact with PPP4C.[7][8]

References

Further reading

Related Articles

Wikiwand AI