CD160

CD160 antigen is a protein that in humans is encoded by the CD160 gene.^[5][6][7]

AliasesCD160, BY55, NK1, NK28, CD160 molecule

External IDsOMIM: 604463; MGI: 1860383; HomoloGene: 5122; GeneCards: CD160; OMA:CD160 - orthologs

Chr.Chromosome 1 (human)^[1]

End145,739,288 bp^[1]

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CD160
Identifiers
Aliases	CD160, BY55, NK1, NK28, CD160 molecule
External IDs	OMIM: 604463; MGI: 1860383; HomoloGene: 5122; GeneCards: CD160; OMA:CD160 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,719,471 bp[1] End 145,739,288 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,706,079 bp[2] End 96,736,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte jejunal mucosa blood testicle spleen duodenum stromal cell of endometrium bone marrow bone marrow cell mononuclear cell Top expressed in secondary oocyte zygote primary oocyte embryo morula embryo ascending aorta aortic valve granulocyte thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding protein binding MHC class I receptor activity signaling receptor activity Cellular component anchored component of membrane anchored component of plasma membrane plasma membrane membrane Biological process cellular defense response cell surface receptor signaling pathway cell population proliferation defense response to Gram-negative bacterium regulation of immune response negative regulation of angiogenesis positive regulation of endothelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11126 54215 Ensembl ENSG00000117281 ENSMUSG00000038304 UniProt O95971 O88875 RefSeq (mRNA) NM_007053 NM_001163496 NM_001163497 NM_018767 RefSeq (protein) NP_008984 NP_001156968 NP_001156969 NP_061237 Location (UCSC) Chr 1: 145.72 – 145.74 Mb Chr 3: 96.71 – 96.74 Mb PubMed search [3] [4]
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CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.^[7]