CD200R1
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[5][6][7] CD200R1 is expressed on the surface of myeloid cells[8] and CD4+ T cells.[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[10] epithelial cells,[11] endothelial cells,[12] fibroblasts,[13] and lymphoid cells.[14]
CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),[15] interferons, and inducible nitric oxide synthase (iNOS).[16]
Function
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[7]
