SLAMF7

SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.^[5][6][7]

AliasesSLAMF7, 19A, CD319, CRACC, CS1, SLAM family member 7

External IDsOMIM: 606625; MGI: 1922595; HomoloGene: 49660; GeneCards: SLAMF7; OMA:SLAMF7 - orthologs

Chr.Chromosome 1 (human)^[1]

End160,754,821 bp^[1]

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SLAMF7
Identifiers
Aliases	SLAMF7, 19A, CD319, CRACC, CS1, SLAM family member 7
External IDs	OMIM: 606625; MGI: 1922595; HomoloGene: 49660; GeneCards: SLAMF7; OMA:SLAMF7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,739,057 bp[1] End 160,754,821 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 171,459,971 bp[2] End 171,480,603 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node epithelium of colon rectum mucosa of sigmoid colon bone marrow cell spleen monocyte palpebral conjunctiva blood Top expressed in interventricular septum spermatocyte spermatid seminiferous tubule spleen mesenteric lymph nodes granulocyte zygote right kidney thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding Cellular component integral component of membrane plasma membrane membrane Biological process cell adhesion natural killer cell activation innate immune response adaptive immune response natural killer cell mediated cytotoxicity regulation of immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57823 75345 Ensembl ENSG00000026751 ENSMUSG00000038179 UniProt Q9NQ25 Q8BHK6 RefSeq (mRNA) NM_001282588 NM_001282589 NM_001282590 NM_001282591 NM_001282592 NM_001282593 NM_001282594 NM_001282595 NM_001282596 NM_021181 NM_144539 NM_001347184 RefSeq (protein) NP_001269517 NP_001269518 NP_001269519 NP_001269520 NP_001269521 NP_001269522 NP_001269523 NP_001269524 NP_001269525 NP_067004 NP_001334113 NP_653122 Location (UCSC) Chr 1: 160.74 – 160.75 Mb Chr 1: 171.46 – 171.48 Mb PubMed search [3] [4]
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The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.^[8]

Elotuzumab is an antibody that targets this protein.