CD8+ cell noncytotoxic anti-HIV response
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CD8+ cell noncytotoxic anti-HIV response appears to be an anti-HIV innate immune response because it can be observed in vitro with CD8+ cells from unexposed and uninfected healthy individuals.[1]
The presence of a CD8+ cell noncytotoxic anti-HIV response (CNAR) was first reported in 1986 by researchers in the laboratory of Dr. Jay Levy at the University of California San Francisco (UCSF).[2] It was recognized that CD8+ cells from HIV-infected individuals can suppress HIV replication without directly killing the infected cells.[3]
CNAR appears to be mediated by a CD8+ cell anti-HIV factor (CAF) that has not yet been identified.[4] Other soluble factors can act against HIV including the β-chemokines.[5]
