CDC2L1

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDK11B gene.^[5][6][7]

AliasesCDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1, cyclin-dependent kinase 11B, cyclin dependent kinase 11B

External IDsOMIM: 176873; MGI: 88353; HomoloGene: 137644; GeneCards: CDK11B; OMA:CDK11B - orthologs

EC number2.7.11.22

Chr.Chromosome 1 (human)^[1]

Quick facts CDK11B, Identifiers ...

CDK11B
Identifiers
Aliases	CDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1, cyclin-dependent kinase 11B, cyclin dependent kinase 11B
External IDs	OMIM: 176873; MGI: 88353; HomoloGene: 137644; GeneCards: CDK11B; OMA:CDK11B - orthologs
EC number	2.7.11.22
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,635,225 bp[1] End 1,659,012 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 86.73 cM Start 155,624,854 bp[2] End 155,649,938 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle gastric mucosa left testis muscle layer of sigmoid colon right testis granulocyte mucosa of transverse colon muscle of thigh right lung Top expressed in granulocyte tail of embryo neural layer of retina saccule genital tubercle otic placode ventricular zone otic vesicle epiblast body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding kinase activity nucleotide binding transferase activity protein serine/threonine kinase activity ATP binding protein kinase activity cyclin-dependent protein serine/threonine kinase activity RNA binding Cellular component nucleus cytoplasm Biological process regulation of transcription, DNA-templated phosphorylation cell cycle regulation of cell growth cell population proliferation regulation of mRNA processing apoptotic process protein phosphorylation regulation of mitotic cell cycle mitotic cell cycle regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 984 12537 Ensembl ENSG00000248333 ENSMUSG00000029062 UniProt P21127 P24788 RefSeq (mRNA) NM_001291345 NM_001787 NM_033486 NM_033487 NM_033488 NM_033489 NM_033490 NM_033492 NM_033493 NM_007661 NM_001347308 NM_001355567 NM_001355568 NM_001355569 RefSeq (protein) NP_001278274 NP_001778 NP_277021 NP_277022 NP_277024 NP_277025 NP_001334237 NP_031687 NP_001342496 NP_001342497 NP_001342498 Location (UCSC) Chr 1: 1.64 – 1.66 Mb Chr 4: 155.62 – 155.65 Mb PubMed search [3] [4]
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This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.^[7]