CDC40

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.^[5][6][7]

AliasesCDC40, EHB3, PRP17, PRPF17, cell division cycle 40, PCH15

External IDsOMIM: 605585; MGI: 1918963; HomoloGene: 5716; GeneCards: CDC40; OMA:CDC40 - orthologs

Chr.Chromosome 6 (human)^[1]

End110,254,275 bp^[1]

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CDC40
Identifiers
Aliases	CDC40, EHB3, PRP17, PRPF17, cell division cycle 40, PCH15
External IDs	OMIM: 605585; MGI: 1918963; HomoloGene: 5716; GeneCards: CDC40; OMA:CDC40 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 110,180,141 bp[1] End 110,254,275 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 40,707,617 bp[2] End 40,759,307 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus sperm mononuclear cell Achilles tendon monocyte secondary oocyte skin of hip mucosa of ileum bone marrow skin of thigh Top expressed in hand lumbar subsegment of spinal cord Rostral migratory stream genital tubercle otolith organ utricle zygote interventricular septum tail of embryo Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleoplasm nucleus U2-type catalytic step 2 spliceosome nuclear speck Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus mRNA 3'-end processing RNA splicing RNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51362 71713 Ensembl ENSG00000168438 ENSMUSG00000038446 UniProt O60508 Q9DC48 RefSeq (mRNA) NM_015891 NM_027879 RefSeq (protein) NP_056975 NP_082155 Location (UCSC) Chr 6: 110.18 – 110.25 Mb Chr 10: 40.71 – 40.76 Mb PubMed search [3] [4]
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Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.^[7]