CDK12

CDK12
Identifiers
Aliases	CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12
External IDs	OMIM: 615514; MGI: 1098802; GeneCards: CDK12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CXA, 4NST, 4UN0, 5ACB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,564,907 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,169,330 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sural nerve; ; secondary oocyte; ; epithelium of colon; ; ganglionic eminence; ; gastric mucosa; ; ventricular zone; ; Achilles tendon; ; skin of leg; ; tonsil;
	Top expressed in
	zygote; ; secondary oocyte; ; ascending aorta; ; tail of embryo; ; Rostral migratory stream; ; aortic valve; ; genital tubercle; ; granulocyte; ; spermatocyte; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; transcription factor binding; protein kinase binding;
Cellular component	nuclear speck; nuclear cyclin-dependent protein kinase holoenzyme complex; cyclin K-CDK12 complex; nucleus; nucleoplasm; fibrillar center; chromosome; cyclin/CDK positive transcription elongation factor complex; cyclin-dependent protein kinase holoenzyme complex;
Biological process	phosphorylation of RNA polymerase II C-terminal domain; phosphorylation; mRNA processing; regulation of cell cycle; protein phosphorylation; regulation of RNA splicing; RNA splicing; protein autophosphorylation; regulation of MAP kinase activity; transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; negative regulation of stem cell differentiation; positive regulation of transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51755
	69131
	ENSG00000167258
	ENSMUSG00000003119
	Q9NYV4
	Q14AX6
	NM_015083; NM_016507
	NM_001109626; NM_001109628; NM_026952
	NP_055898; NP_057591
	NP_001103096; NP_001103098; NP_081228
	Wikidata
View/Edit Human	View/Edit Mouse

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene.^[5]^[6]^[7] This enzyme is a member of cyclin-dependent kinase protein family.