CDK12

CDK12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CXA, 4NST, 4UN0, 5ACB
Identifiers
Aliases	CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12
External IDs	OMIM: 615514; MGI: 1098802; HomoloGene: 128632; GeneCards: CDK12; OMA:CDK12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,564,907 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,169,330 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sural nerve; ; secondary oocyte; ; epithelium of colon; ; ganglionic eminence; ; gastric mucosa; ; ventricular zone; ; Achilles tendon; ; skin of leg; ; tonsil;
	Top expressed in
	zygote; ; secondary oocyte; ; ascending aorta; ; tail of embryo; ; Rostral migratory stream; ; aortic valve; ; genital tubercle; ; granulocyte; ; spermatocyte; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; transcription factor binding; protein kinase binding;
Cellular component	nuclear speck; nuclear cyclin-dependent protein kinase holoenzyme complex; cyclin K-CDK12 complex; nucleus; nucleoplasm; fibrillar center; chromosome; cyclin/CDK positive transcription elongation factor complex; cyclin-dependent protein kinase holoenzyme complex;
Biological process	phosphorylation of RNA polymerase II C-terminal domain; phosphorylation; mRNA processing; regulation of cell cycle; protein phosphorylation; regulation of RNA splicing; RNA splicing; protein autophosphorylation; regulation of MAP kinase activity; transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; negative regulation of stem cell differentiation; positive regulation of transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	51755
	69131
	ENSG00000167258
	ENSMUSG00000003119
	Q9NYV4
	Q14AX6
	NM_015083; NM_016507
	NM_001109626; NM_001109628; NM_026952
	NP_055898; NP_057591
	NP_001103096; NP_001103098; NP_081228
	Wikidata
View/Edit Human	View/Edit Mouse

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene.^[5]^[6]^[7] This enzyme is a member of cyclin-dependent kinase protein family.