CDK2AP1
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.[5][6][7]
| CDK2AP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CDK2AP1, DOC1, DORC1, ST19, doc-1, p12DOC-1, cyclin-dependent kinase 2 associated protein 1, cyclin dependent kinase 2 associated protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602198; MGI: 1202069; HomoloGene: 3411; GeneCards: CDK2AP1; OMA:CDK2AP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.[7]
Interactions
CDK2AP1 has been shown to interact with Cyclin-dependent kinase 2.[8]
It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.[9]
