CDK5RAP1

CDK5 regulatory subunit-associated protein 1 is a protein that in humans is encoded by the CDK5RAP1 gene.^[5][6][7][8]

AliasesCDK5RAP1, C20orf34, C42, CGI-05, HSPC167, CDK5 regulatory subunit associated protein 1

External IDsOMIM: 608200; MGI: 1914221; HomoloGene: 9502; GeneCards: CDK5RAP1; OMA:CDK5RAP1 - orthologs

Chr.Chromosome 20 (human)^[1]

End33,401,561 bp^[1]

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CDK5RAP1
Identifiers
Aliases	CDK5RAP1, C20orf34, C42, CGI-05, HSPC167, CDK5 regulatory subunit associated protein 1
External IDs	OMIM: 608200; MGI: 1914221; HomoloGene: 9502; GeneCards: CDK5RAP1; OMA:CDK5RAP1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 33,358,839 bp[1] End 33,401,561 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,177,300 bp[2] End 154,214,930 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right lobe of thyroid gland apex of heart left lobe of thyroid gland skin of leg cerebellar hemisphere right hemisphere of cerebellum skin of abdomen gonad spleen Top expressed in primary oocyte muscle of thigh right kidney proximal tubule morula thoracic diaphragm spermatocyte skeletal muscle tissue blastocyst soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding transferase activity iron-sulfur cluster binding catalytic activity protein kinase binding metal ion binding N6-isopentenyladenosine methylthiotransferase activity 4 iron, 4 sulfur cluster binding Cellular component cytoplasm mitochondrion cellular component Biological process regulation of neuron differentiation brain development regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cyclin-dependent protein serine/threonine kinase activity tRNA modification positive regulation of mitochondrial translation mitochondrial tRNA modification positive regulation of translational fidelity tRNA methylthiolation RNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51654 66971 Ensembl ENSG00000101391 ENSMUSG00000027487 UniProt Q96SZ6 Q8BTW8 RefSeq (mRNA) NM_001278167 NM_001278168 NM_001278169 NM_016082 NM_016408 NM_001365728 NM_025876 RefSeq (protein) NP_001265096 NP_001265097 NP_001265098 NP_057166 NP_057492 NP_001352657 NP_080152 Location (UCSC) Chr 20: 33.36 – 33.4 Mb Chr 2: 154.18 – 154.21 Mb PubMed search [3] [4]
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Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.^[8]