CEBPD
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[5][6]
Function
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]
Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]
Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[11]
