CELA3A
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.[5][6][7] CELA3A is a digestive enzyme found in pancreatic juice, which functions to break protein bonds.[7] Like its paralog CELA3B, it is a pancreatic endopeptidase E.[8] Despite sometimes being referred to as an elastase, it has little ability to break down elastin,[7] but it is able to bind cholesterol,[8] and may be involved in cholesterol metabolism.[7]
| CELA3A | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CELA3A, ELA3, ELA3A, chymotrypsin like elastase family member 3A, chymotrypsin like elastase 3A | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3651647; GeneCards: CELA3A | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase family genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 3A is secreted from the acinar cells of the pancreas as an inactive zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.[7]