CGB7

Choriogonadotropin subunit beta is a protein that in humans is encoded by the CGB7 gene.^[3][4]

AliasesCGB7, CG-beta-a, CGB6, chorionic gonadotropin beta subunit 7, chorionic gonadotropin subunit beta 7

External IDsOMIM: 608826; GeneCards: CGB7

PDBHuman UniProt search: PDBe RCSB

Chr.Chromosome 19 (human)^[1]

Quick facts Identifiers, Aliases ...

CGB7
Identifiers
Aliases	CGB7, CG-beta-a, CGB6, chorionic gonadotropin beta subunit 7, chorionic gonadotropin subunit beta 7
External IDs	OMIM: 608826; GeneCards: CGB7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1HCN, 1HRP, 1QFW
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,054,274 bp[1] End 49,058,860 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg olfactory zone of nasal mucosa stromal cell of endometrium muscle of thigh skeletal muscle tissue gastrocnemius muscle prostate gonad vagina n/a More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity Cellular component extracellular region extracellular space cytoplasm Biological process peptide hormone processing apoptotic process signal transduction female gamete generation cell-cell signaling regulation of signaling receptor activity hormone-mediated signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 94027 n/a Ensembl ENSG00000196337 n/a UniProt P0DN87 n/a RefSeq (mRNA) NM_033142 NM_001385261 n/a RefSeq (protein) NP_000728.1 NP_149032.1 NP_149133.1 NP_149439.1 NP_149133 n/a Location (UCSC) Chr 19: 49.05 – 49.06 Mb n/a PubMed search [2] n/a
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This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.^[4]