CHRNB2

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesCHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit

External IDsOMIM: 118507; MGI: 87891; HomoloGene: 595; GeneCards: CHRNB2; OMA:CHRNB2 - orthologs

Chr.Chromosome 1 (human)^[1]

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CHRNB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K58, 2K59, 2KSR, 2LM2
Identifiers
Aliases	CHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
External IDs	OMIM: 118507; MGI: 87891; HomoloGene: 595; GeneCards: CHRNB2; OMA:CHRNB2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,567,778 bp[1] End 154,580,013 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.19 cM Start 89,653,502 bp[2] End 89,671,939 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell vena cava lateral nuclear group of thalamus pars reticulata external globus pallidus subthalamic nucleus mucosa of pharynx ventral tegmental area body of tongue pars compacta Top expressed in medial dorsal nucleus medial geniculate nucleus lateral geniculate nucleus habenula cerebellar cortex glomerulus dentate gyrus of hippocampal formation granule cell dorsal tegmental nucleus superior colliculus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine binding acetylcholine receptor activity ion channel activity protein binding ligand-gated ion channel activity protein heterodimerization activity extracellular ligand-gated ion channel activity acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component acetylcholine-gated channel complex integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction external side of plasma membrane integral component of plasma membrane neuron projection plasma membrane raft dopaminergic synapse cholinergic synapse integral component of presynaptic membrane integral component of postsynaptic specialization membrane Biological process visual learning regulation of synaptic transmission, dopaminergic response to cocaine smooth muscle contraction regulation of circadian sleep/wake cycle, REM sleep regulation of dopamine secretion response to hypoxia associative learning cognition locomotory behavior protein heterooligomerization central nervous system neuron axonogenesis optic nerve morphogenesis regulation of synapse assembly regulation of membrane potential response to nicotine membrane depolarization nervous system process synaptic transmission, cholinergic ion transport hearing learning memory negative regulation of action potential regulation of dopamine metabolic process behavioral response to nicotine regulation of dendrite morphogenesis B cell activation neuromuscular synaptic transmission synaptic transmission involved in micturition positive regulation of dopamine secretion positive regulation of B cell proliferation regulation of circadian sleep/wake cycle, non-REM sleep vestibulocochlear nerve development conditioned taste aversion transport social behavior action potential sensory perception of pain lateral geniculate nucleus development positive regulation of synaptic transmission, dopaminergic response to ethanol central nervous system projection neuron axonogenesis calcium ion transport signal transduction visual perception ion transmembrane transport regulation of postsynaptic membrane potential excitatory postsynaptic potential acetylcholine receptor signaling pathway chemical synaptic transmission response to acetylcholine regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1141 11444 Ensembl ENSG00000160716 ENSMUSG00000027950 UniProt P17787 Q9ERK7 RefSeq (mRNA) NM_000748 NM_009602 RefSeq (protein) NP_000739 NP_033732 Location (UCSC) Chr 1: 154.57 – 154.58 Mb Chr 3: 89.65 – 89.67 Mb PubMed search [3] [4]
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Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.^[6]

It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.