CIDEA

Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene.^[5][6][7] Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.^[8]

PDBOrtholog search: PDBe RCSB

AliasesCIDEA, CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a

External IDsOMIM: 604440; MGI: 1270845; HomoloGene: 77852; GeneCards: CIDEA; OMA:CIDEA - orthologs

Chr.Chromosome 18 (human)^[1]

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CIDEA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EEL
Identifiers
Aliases	CIDEA, CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a
External IDs	OMIM: 604440; MGI: 1270845; HomoloGene: 77852; GeneCards: CIDEA; OMA:CIDEA - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.21|18 Start 12,254,361 bp[1] End 12,277,595 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 67,476,674 bp[2] End 67,500,855 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in abdominal fat subcutaneous adipose tissue skin of thigh vulva synovial joint skin of arm skin of abdomen human penis prefrontal cortex pericardium Top expressed in tunica adventitia of aorta intercostal muscle skin of external ear parotid gland lip tunica media of zone of aorta mammary gland subcutaneous adipose tissue trachea brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity Cellular component cytoplasm lipid droplet intracellular anatomical structure mitochondrion mitochondrial envelope nucleus cytosol Biological process regulation of apoptotic process negative regulation of execution phase of apoptosis regulation of transcription, DNA-templated lipid metabolism lipid storage cell death negative regulation of transforming growth factor beta receptor signaling pathway transcription, DNA-templated positive regulation of sequestering of triglyceride response to stilbenoid negative regulation of tumor necrosis factor production temperature homeostasis negative regulation of lipid catabolic process regulation of apoptotic DNA fragmentation apoptotic process lipid droplet organization negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1149 12683 Ensembl ENSG00000176194 ENSMUSG00000024526 UniProt O60543 O70302 RefSeq (mRNA) NM_001279 NM_001318383 NM_007702 RefSeq (protein) NP_001270 NP_001305312 NP_031728 Location (UCSC) Chr 18: 12.25 – 12.28 Mb Chr 18: 67.48 – 67.5 Mb PubMed search [3] [4]
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This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.^[7]