CLDN18
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[5] It belongs to the group of claudins.
External IDsOMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[6] [supplied by OMIM][5]
Clinical significance
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[7]
Zolbetuximab targets Claudin 18.2 to help treat gastric and gastroesophageal junction cancers.[8][9] [10]