CLDN18

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[5] It belongs to the group of claudins.

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CLDN18
Identifiers
AliasesCLDN18, SFTA5, SFTPJ, claudin 18
External IDsOMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016369
NM_001002026

NM_001194921
NM_001194922
NM_001194923
NM_019815

RefSeq (protein)

NP_001002026
NP_057453

NP_001181850
NP_001181851
NP_001181852
NP_062789

Location (UCSC)Chr 3: 138 – 138.03 MbChr 9: 99.57 – 99.6 Mb
PubMed search[3][4]
Wikidata
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CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[6] [supplied by OMIM][5]

Clinical significance

Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[7]

Zolbetuximab targets Claudin 18.2 to help treat gastric and gastroesophageal junction cancers.[8][9] [10]

References

Further reading

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