CLEC4M

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.^[5] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

PDBOrtholog search: PDBe RCSB

AliasesCLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M

External IDsOMIM: 605872; MGI: 2157942; HomoloGene: 129771; GeneCards: CLEC4M; OMA:CLEC4M - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts Available structures, PDB ...

CLEC4M
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K9J, 1SL6, 1XAR, 1XPH, 3JQH
Identifiers
Aliases	CLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDs	OMIM: 605872; MGI: 2157942; HomoloGene: 129771; GeneCards: CLEC4M; OMA:CLEC4M - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,763,210 bp[1] End 7,769,605 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 3,793,397 bp[2] End 3,798,984 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver germinal epithelium lymph node pancreatic ductal cell right lung testicle placenta left ovary right adrenal gland left adrenal cortex Top expressed in granulocyte lip skin of abdomen right kidney muscle of thigh spleen right lung lobe white adipose tissue carotid body skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding virus receptor activity metal ion binding calcium-dependent protein binding mannose binding virion binding ICAM-3 receptor activity carbohydrate binding signaling receptor activity protein binding Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region host cell Biological process leukocyte cell-cell adhesion cell-cell recognition intracellular transport of virus intracellular signal transduction antigen processing and presentation endocytosis adaptive immune response immune system process viral genome replication peptide antigen transport modulation by virus of host process innate immune response viral process virion attachment to host cell viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10332 170786 Ensembl ENSG00000104938 ENSMUSG00000031494 UniProt Q9H2X3 Q91ZX1 RefSeq (mRNA) NM_001144904 NM_001144905 NM_001144906 NM_001144907 NM_001144908 NM_001144909 NM_001144910 NM_001144911 NM_014257 NM_214675 NM_214676 NM_133238 RefSeq (protein) NP_001138376 NP_001138377 NP_001138378 NP_001138379 NP_001138380 NP_001138381 NP_001138382 NP_001138383 NP_055072 NP_573501 Location (UCSC) Chr 19: 7.76 – 7.77 Mb Chr 8: 3.79 – 3.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.^[6]