CLK3 (gene)

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene.^[5][6] The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.^[7]

PDBOrtholog search: PDBe RCSB

AliasesCLK3, PHPHCLK3/152, CDC like kinase 3

External IDsOMIM: 602990; MGI: 1098670; HomoloGene: 101534; GeneCards: CLK3; OMA:CLK3 - orthologs

Chr.Chromosome 15 (human)^[1]

Quick facts Available structures, PDB ...

CLK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EU9, 2EXE, 2WU6, 2WU7, 3RAW
Identifiers
Aliases	CLK3, PHPHCLK3/152, CDC like kinase 3
External IDs	OMIM: 602990; MGI: 1098670; HomoloGene: 101534; GeneCards: CLK3; OMA:CLK3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 74,598,500 bp[1] End 74,645,414 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 57,657,907 bp[2] End 57,673,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte left testis right testis monocyte anterior pituitary left lobe of thyroid gland mucosa of transverse colon skin of leg minor salivary glands skin of abdomen Top expressed in thymus granulocyte lip muscle of thigh aortic valve ascending aorta neural layer of retina fetal liver hematopoietic progenitor cell superior surface of tongue spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity protein binding protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding identical protein binding RNA binding Cellular component cytoplasm nuclear speck membrane nucleoplasm acrosomal vesicle intermediate filament cytoskeleton cytoplasmic vesicle nucleus Biological process phosphorylation protein phosphorylation regulation of RNA splicing protein autophosphorylation peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1198 102414 Ensembl ENSG00000179335 ENSMUSG00000032316 UniProt P49761 O35492 RefSeq (mRNA) NM_001130028 NM_001292 NM_003992 NM_007713 RefSeq (protein) NP_001123500 NP_003983 NP_031739 Location (UCSC) Chr 15: 74.6 – 74.65 Mb Chr 9: 57.66 – 57.67 Mb PubMed search [3] [4]
Wikidata
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