CLYBL

CLYBL
Identifiers
Aliases	CLYBL, CLB, citrate lyase beta like, citramalyl-CoA lyase
External IDs	OMIM: 609686; MGI: 1916884; GeneCards: CLYBL
Enzyme activity
Gene location (Human)
Chr.	Chromosome 13 (human)
End	99,897,134 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	122,639,646 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; human kidney; ; muscle of thigh; ; mucosa of transverse colon; ; gastrocnemius muscle; ; rectum; ; vastus lateralis muscle; ; left ventricle; ; apex of heart; ; jejunal mucosa;
	Top expressed in
	interventricular septum; ; right kidney; ; brown adipose tissue; ; myocardium of ventricle; ; human kidney; ; proximal tubule; ; secondary oocyte; ; intercostal muscle; ; cardiac muscles; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; catalytic activity; malate synthase activity; magnesium ion binding; metal ion binding; lyase activity; (S)-citramalyl-CoA lyase activity;
Cellular component	mitochondrion; membrane; integral component of membrane;
Biological process	protein homotrimerization; regulation of cobalamin metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	171425
	69634
	ENSG00000125246
	ENSMUSG00000025545
	Q8N0X4; Q5JVC1
	Q8R4N0
	NM_206808
	NM_029556
	NP_996531
	NP_083832
	Wikidata
View/Edit Human	View/Edit Mouse

Citramalyl-CoA lyase, mitochondrial is an enzyme that in humans is encoded by the CLYBL gene.^[5] One of its main functions involves participating in the detoxification of poisonous vitamin B12 metabolites in the mitochondria.^[6] As part of that it converts citramalyl-CoA into acetyl-CoA and pyruvate (acting as a Citramalyl-CoA lyase), and can also detoxify malyl-CoA (acting as a malyl-CoA thioesterase).^[6] It has also been shown to be able to act as a malate synthase, but only in vitro in the lab.^[6]