CMKLR2

Chemerin-like receptor 2, is a protein that in humans is encoded by the CMKLR2 gene.^[5][6]

AliasesCMKLR2, G protein-coupled receptor 1, chemerin chemokine-like receptor 2, GPR1

External IDsOMIM: 600239; MGI: 2385324; HomoloGene: 21094; GeneCards: CMKLR2; OMA:CMKLR2 - orthologs

Chr.Chromosome 2 (human)^[1]

End206,218,047 bp^[1]

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CMKLR2
Identifiers
Aliases	CMKLR2, G protein-coupled receptor 1, chemerin chemokine-like receptor 2, GPR1
External IDs	OMIM: 600239; MGI: 2385324; HomoloGene: 21094; GeneCards: CMKLR2; OMA:CMKLR2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 206,175,316 bp[1] End 206,218,047 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 63,221,850 bp[2] End 63,253,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta stromal cell of endometrium testicle mucosa of esophagus skin of leg right adrenal cortex ventricular zone left adrenal gland gallbladder left adrenal cortex Top expressed in primary oocyte secondary oocyte zygote placenta urethra female urethra decidua male urethra epithelium of urethra epithelium of male urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding signal transducer activity protein binding G protein-coupled receptor activity peptide binding Cellular component membrane integral component of membrane integral component of plasma membrane neuron projection plasma membrane intracellular membrane-bounded organelle nucleoplasm Biological process chemical synaptic transmission neuropeptide signaling pathway G protein-coupled receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2825 241070 Ensembl ENSG00000183671 ENSG00000283448 ENSMUSG00000046856 UniProt P46091 Q8K087 RefSeq (mRNA) NM_001098199 NM_001261452 NM_001261453 NM_001261454 NM_001261455 NM_005279 NM_001389445 NM_146250 NM_001357045 RefSeq (protein) NP_001091669 NP_001248381 NP_001248382 NP_001248383 NP_001248384 NP_005270 NP_666362 NP_001343974 Location (UCSC) Chr 2: 206.18 – 206.22 Mb Chr 1: 63.22 – 63.25 Mb PubMed search [3] [4]
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CMKLR2 is a rhodopsin-like receptor and therefore a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin.^[7] Other receptors for chemerin include CMKLR1 and CCRL2.