COG8

Conserved oligomeric Golgi complex subunit 8 is a protein that in humans is encoded by the COG8 gene.^[5][6]

AliasesCOG8, CDG2H, DOR1, component of oligomeric golgi complex 8

External IDsOMIM: 606979; MGI: 2142885; HomoloGene: 13018; GeneCards: COG8; OMA:COG8 - orthologs

Chr.Chromosome 16 (human)^[1]

End69,339,667 bp^[1]

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COG8
Identifiers
Aliases	COG8, CDG2H, DOR1, component of oligomeric golgi complex 8
External IDs	OMIM: 606979; MGI: 2142885; HomoloGene: 13018; GeneCards: COG8; OMA:COG8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,320,140 bp[1] End 69,339,667 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 107,772,921 bp[2] End 107,783,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm tibialis anterior muscle stromal cell of endometrium gastrocnemius muscle mucosa of ileum right adrenal gland cerebellar vermis right adrenal cortex muscle of thigh left adrenal gland Top expressed in otic vesicle saccule seminiferous tubule otic placode spermatid spermatocyte muscle of thigh granulocyte interventricular septum right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane Golgi transport complex trans-Golgi network membrane Golgi membrane Golgi apparatus Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84342 97484 Ensembl ENSG00000213380 ENSMUSG00000031916 UniProt Q96MW5 Q9JJA2 RefSeq (mRNA) NM_032382 NM_001374871 NM_139229 RefSeq (protein) NP_115758 NP_631975 Location (UCSC) Chr 16: 69.32 – 69.34 Mb Chr 8: 107.77 – 107.78 Mb PubMed search [3] [4]
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Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi complex (COG), which includes COG8 (Ungar et al., 2002).[supplied by OMIM]^[6]