COPS4

COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.^[5][6]

AliasesCOPS4, CSN4, COP9 signalosome subunit 4, SGN4

External IDsOMIM: 616008; MGI: 1349414; GeneCards: COPS4

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 4 (human)^[1]

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COPS4
Identifiers
Aliases	COPS4, CSN4, COP9 signalosome subunit 4, SGN4
External IDs	OMIM: 616008; MGI: 1349414; GeneCards: COPS4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D0P, 4D10, 4D18, 4WSN
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.22 Start 83,034,447 bp[1] End 83,075,818 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E4|5 48.49 cM Start 100,666,175 bp[2] End 100,695,669 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii vastus lateralis muscle deltoid muscle Skeletal muscle tissue of biceps brachii glutes thoracic diaphragm Skeletal muscle tissue of rectus abdominis tibialis anterior muscle right ventricle secondary oocyte Top expressed in spermatid spermatocyte maxillary prominence mandibular prominence tail of embryo otic vesicle seminiferous tubule genital tubercle otic placode supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding NEDD8-specific protease activity Cellular component cytoplasm COP9 signalosome cell junction synapse extracellular exosome cytoplasmic vesicle synaptic vesicle nucleus nucleoplasm cytosol nuclear speck Biological process transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA damage recognition protein deneddylation post-translational protein modification Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51138 26891 Ensembl ENSG00000138663 ENSMUSG00000035297 UniProt Q9BT78 O88544 RefSeq (mRNA) NM_001258006 NM_016129 NM_001330727 NM_012001 NM_001359203 NM_001359204 RefSeq (protein) NP_001244935 NP_001317656 NP_057213 NP_036131 NP_001346132 NP_001346133 Location (UCSC) Chr 4: 83.03 – 83.08 Mb Chr 5: 100.67 – 100.7 Mb PubMed search [3] [4]
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This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.^[6]