CORO1B
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Function
A mammalian coronin enriches at the leading edge of migrating cells.[3] Studies related to this protein are as follows:
- Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.[4]
- F-actin binding is essential for coronin 1B function in vivo.[5]
- Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.[6]
- Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.[2]
- In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.[7]
- Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.[8]
