COX6C

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.^[4][5]

AliasesCOX6C, cytochrome c oxidase subunit 6C

External IDsOMIM: 124090; HomoloGene: 136781; GeneCards: COX6C; OMA:COX6C - orthologs

Chr.Chromosome 8 (human)^[1]

End99,893,707 bp^[1]

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COX6C
Identifiers
Aliases	COX6C, cytochrome c oxidase subunit 6C
External IDs	OMIM: 124090; HomoloGene: 136781; GeneCards: COX6C; OMA:COX6C - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 99,873,200 bp[1] End 99,893,707 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons ventricle of the heart left ventricle body of tongue right ventricle superior vestibular nucleus Skeletal muscle tissue of rectus abdominis apex of heart biceps brachii right auricle of heart n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytochrome-c oxidase activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion Biological process proton transmembrane transport generation of precursor metabolites and energy electron transport chain mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1345 102640946 Ensembl ENSG00000164919 n/a UniProt P09669 n/a RefSeq (mRNA) NM_004374 n/a RefSeq (protein) NP_004365 n/a Location (UCSC) Chr 8: 99.87 – 99.89 Mb n/a PubMed search [2] [3]
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Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.^[5]