COX7C

Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.^[5][6]

AliasesCOX7C, cytochrome c oxidase subunit 7C

External IDsOMIM: 603774; MGI: 103226; HomoloGene: 135674; GeneCards: COX7C; OMA:COX7C - orthologs

Chr.Chromosome 5 (human)^[1]

End86,620,962 bp^[1]

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COX7C
Identifiers
Aliases	COX7C, cytochrome c oxidase subunit 7C
External IDs	OMIM: 603774; MGI: 103226; HomoloGene: 135674; GeneCards: COX7C; OMA:COX7C - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.3 Start 86,617,928 bp[1] End 86,620,962 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 86,192,935 bp[2] End 86,195,023 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle right auricle of heart left ventricle apex of heart muscle of thigh human kidney prefrontal cortex ganglionic eminence biceps brachii mucosa of transverse colon Top expressed in quadriceps femoris muscle right kidney yolk sac heart proximal tubule stomach muscle tissue neural tube skeletal muscle tissue jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytochrome-c oxidase activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion mitochondrial respiratory chain complex IV Biological process proton transmembrane transport generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1350 12867 Ensembl ENSG00000127184 ENSMUSG00000017778 UniProt P15954 P17665 RefSeq (mRNA) NM_001867 NM_007749 RefSeq (protein) NP_001858 NP_031775 Location (UCSC) Chr 5: 86.62 – 86.62 Mb Chr 13: 86.19 – 86.2 Mb PubMed search [3] [4]
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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.^[6]