CPHPC

CPHPC ((R)-1-{6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl}pyrrolidine-2-carboxylic acid) is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.^[1]

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CPHPC

Names
Preferred IUPAC name (2R,2′R)-1,1′-Hexanedioyldi(pyrrolidine-2-carboxylic acid)
Other names Ro 63-8695
Identifiers
CAS Number	224624-80-0 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL25263 Y
ChemSpider	111662 Y
ECHA InfoCard	100.262.818
IUPHAR/BPS	8256
PubChem CID	125516
UNII	WO97N24A47 N
CompTox Dashboard (EPA)	DTXSID00176996
InChI InChI=1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1 Y Key: HZLAWYIBLZNRFZ-VXGBXAGGSA-N Y InChI=1/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1 Key: HZLAWYIBLZNRFZ-VXGBXAGGBC
SMILES O=C(O)[C@@H]2N(C(=O)CCCCC(=O)N1[C@@H](C(=O)O)CCC1)CCC2
Properties
Chemical formula	C16H24N2O6
Molar mass	340.37 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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CPHPC has also been patented for possible treatment of Alzheimer's disease.^[2]