CPNE4

Copine-4 is a protein that in humans is encoded by the CPNE4 gene.^[5][6][7]

AliasesCPNE4, COPN4, CPN4, copine 4

External IDsOMIM: 604208; MGI: 1921270; HomoloGene: 26078; GeneCards: CPNE4; OMA:CPNE4 - orthologs

Chr.Chromosome 3 (human)^[1]

End132,285,410 bp^[1]

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CPNE4
Identifiers
Aliases	CPNE4, COPN4, CPN4, copine 4
External IDs	OMIM: 604208; MGI: 1921270; HomoloGene: 26078; GeneCards: CPNE4; OMA:CPNE4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1 Start 131,533,555 bp[1] End 132,285,410 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 104,424,485 bp[2] End 104,911,743 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus myocardium of left ventricle endothelial cell primary visual cortex Brodmann area 23 palpebral conjunctiva dorsolateral prefrontal cortex Brodmann area 9 Brodmann area 46 right ventricle Top expressed in dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion hippocampus proper trigeminal ganglion primary visual cortex habenula superior frontal gyrus olfactory bulb temporal lobe glossopharyngeal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calcium-dependent phospholipid binding Cellular component extracellular exosome plasma membrane Biological process cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131034 74020 Ensembl ENSG00000196353 ENSMUSG00000032564 UniProt Q96A23 Q4G168 Q8BLR2 RefSeq (mRNA) NM_001289112 NM_130808 NM_153429 NM_001388326 NM_001388327 NM_028719 NM_001357439 NM_001378996 RefSeq (protein) NP_001276041 NP_570720 NP_702907 NP_001276041.1 NP_570720.1 NP_702907.1 NP_082995 NP_001344368 NP_001365925 Location (UCSC) Chr 3: 131.53 – 132.29 Mb Chr 9: 104.42 – 104.91 Mb PubMed search [3] [4]
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Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm.

This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.^[7]