CPSF3

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.^[5][6]

AliasesCPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3

External IDsOMIM: 606029; MGI: 1859328; GeneCards: CPSF3

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

Quick facts Identifiers, Aliases ...

CPSF3
Identifiers
Aliases	CPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3
External IDs	OMIM: 606029; MGI: 1859328; GeneCards: CPSF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I7T, 2I7V
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 9,423,651 bp[1] End 9,473,101 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.3 Start 21,335,392 bp[2] End 21,365,057 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone left testis right testis endothelial cell tendon of biceps brachii sperm monocyte stromal cell of endometrium islet of Langerhans Top expressed in primitive streak medullary collecting duct ureter internal carotid artery condyle fossa vas deferens Epithelium of choroid plexus external carotid artery endothelial cell of lymphatic vessel More reference expression data BioGPS n/a
Gene ontology Molecular function 5'-3' exonuclease activity metal ion binding endoribonuclease activity protein binding RNA binding nuclease activity endonuclease activity hydrolase activity Cellular component mRNA cleavage and polyadenylation specificity factor complex nucleoplasm nucleus Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA 3'-end processing by stem-loop binding and cleavage mRNA processing mRNA export from nucleus mRNA polyadenylation mRNA cleavage mRNA 3'-end processing RNA phosphodiester bond hydrolysis, endonucleolytic sno(s)RNA 3'-end processing snoRNA splicing pre-mRNA cleavage required for polyadenylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51692 54451 Ensembl ENSG00000119203 ENSMUSG00000054309 UniProt Q9UKF6 Q9QXK7 RefSeq (mRNA) NM_016207 NM_001321833 NM_001321834 NM_001321835 NM_001321836 NM_018813 NM_001364372 NM_001364373 RefSeq (protein) NP_001308762 NP_001308763 NP_001308764 NP_001308765 NP_057291 NP_061283 NP_001351301 NP_001351302 Location (UCSC) Chr 2: 9.42 – 9.47 Mb Chr 12: 21.34 – 21.37 Mb PubMed search [3] [4]
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