CST11

Cystatin-11 is a protein that in humans is encoded by the CST11 gene.^[5]

AliasesCST11, CST8L, CTES2, SC13, dJ322G13.6, cystatin 11

External IDsOMIM: 609731; MGI: 1925490; HomoloGene: 15634; GeneCards: CST11; OMA:CST11 - orthologs

Chr.Chromosome 20 (human)^[1]

End23,452,876 bp^[1]

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CST11
Identifiers
Aliases	CST11, CST8L, CTES2, SC13, dJ322G13.6, cystatin 11
External IDs	OMIM: 609731; MGI: 1925490; HomoloGene: 15634; GeneCards: CST11; OMA:CST11 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,450,403 bp[1] End 23,452,876 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 148,610,529 bp[2] End 148,613,417 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis gonad buccal mucosa cell caput epididymis tail of epididymis decidua stromal cell of endometrium granulocyte mucosa of nose fundus Top expressed in embryo morula dorsal striatum white adipose tissue foregut gonad stomach testicle gastrula More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity protease binding cysteine-type endopeptidase inhibitor activity Cellular component sperm flagellum sperm head extracellular space extracellular region nucleus cytoplasm Biological process negative regulation of peptidase activity defense response to bacterium androgen receptor signaling pathway defense response to Gram-negative bacterium negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140880 78240 Ensembl ENSG00000125831 ENSMUSG00000036958 UniProt Q9H112 Q9D269 RefSeq (mRNA) NM_130794 NM_080830 NM_030059 RefSeq (protein) NP_543020 NP_570612 NP_084335 Location (UCSC) Chr 20: 23.45 – 23.45 Mb Chr 2: 148.61 – 148.61 Mb PubMed search [3] [4]
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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity.

There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions.

The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct isoforms.^[5]