CSTF1

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.^[5][6][7]

AliasesCSTF1, CstF-50, CstFp50, cleavage stimulation factor subunit 1

External IDsOMIM: 600369; MGI: 1914587; HomoloGene: 1012; GeneCards: CSTF1; OMA:CSTF1 - orthologs

Chr.Chromosome 20 (human)^[1]

End56,406,362 bp^[1]

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CSTF1
Identifiers
Aliases	CSTF1, CstF-50, CstFp50, cleavage stimulation factor subunit 1
External IDs	OMIM: 600369; MGI: 1914587; HomoloGene: 1012; GeneCards: CSTF1; OMA:CSTF1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.2-q13.31 Start 56,392,371 bp[1] End 56,406,362 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 94.84 cM Start 172,212,601 bp[2] End 172,224,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle secondary oocyte Achilles tendon gonad islet of Langerhans stromal cell of endometrium ventricular zone rectum granulocyte body of pancreas Top expressed in spermatid seminiferous tubule spermatocyte yolk sac epiblast ventricular zone secondary oocyte Ileal epithelium tail of embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component nucleus nucleoplasm mRNA cleavage stimulating factor complex Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1477 67337 Ensembl ENSG00000101138 ENSMUSG00000027498 UniProt Q05048 Q99LC2 RefSeq (mRNA) NM_001033521 NM_001033522 NM_001324 NM_024199 RefSeq (protein) NP_001028693 NP_001028694 NP_001315 NP_077161 Location (UCSC) Chr 20: 56.39 – 56.41 Mb Chr 2: 172.21 – 172.22 Mb PubMed search [3] [4]
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This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.^[7]