CUMYL-4CN-BINACA

CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug.^{[3][4][5][6][7][8]} It is a potent agonist for cannabinoid receptors CB₁ and CB₂, with in vitro EC₅₀ values of 0.58 nM and 6.12 nM, respectively.^[9] In mice, CUMYL-4CN-BINACA produces hypothermic and pro-convulsant effects via the CB₁ receptor,^[9] and anecdotal reports suggest it has an active dose of around 0.1 mg in humans.^[10]

Legal status

• AU: S9 (Prohibited substance)
• BR: Class F2 (Prohibited psychotropics)^[1]
• CA: Schedule II
• DE: Anlage II (Authorized trade only, not prescriptible)
• UK: Class B
• US: Schedule I
• UN: Psychotropic Schedule II^[2]

CAS Number

• 1631074-54-8

PubChem CID

• 117650402

ChemSpider

• 58190345

Quick facts Legal status, Identifiers ...

CUMYL-4CN-BINACA

Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B US: Schedule I UN: Psychotropic Schedule II[2]
Identifiers
IUPAC name 1-(4-Cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide
CAS Number	1631074-54-8
PubChem CID	117650402
ChemSpider	58190345
UNII	V6DM582RV1
KEGG	C22722
CompTox Dashboard (EPA)	DTXSID401009982
Chemical and physical data
Formula	C22H24N4O
Molar mass	360.461 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(NC(C)(C)C1=CC=CC=C1)C2=NN(CCCCC#N)C3=C2C=CC=C3
InChI InChI=1S/C22H24N4O/c1-22(2,17-11-5-3-6-12-17)24-21(27)20-18-13-7-8-14-19(18)26(25-20)16-10-4-9-15-23/h3,5-8,11-14H,4,9-10,16H2,1-2H3,(H,24,27) Key:JGTSOWOPISVAHG-UHFFFAOYSA-N

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CUMYL-4CN-BINACA is metabolized to produce cyanide, raising concerns about liver toxicity.^[8] There is one reported case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.^[11]