CVN45502

CVN45502 is a selective hypocretin (orexin) receptor 1 antagonist. It significantly reduces food intake and body weight in a mouse model of obesity.^[1] Although HCRTR1 variants are significantly correlated with body weight in humans, it is not known if the drug has psychiatric side effects or could be combined with GLP-1 agonists.^[2]

Legal status

• Investigational

CAS Number

• 1803556-98-0 ^Y

PubChem CID

• 118308152

ChemSpider

• 76767388

Quick facts Legal status, Identifiers ...

CVN45502

Legal status
Legal status	Investigational
Identifiers
IUPAC name N-[(1S,2S)-2-Methyl-2-[[5-(trifluoromethyl)pyrazin-2-yl]amino]cyclopentyl]-3-(triazol-2-yl)pyridine-2-carboxamide
CAS Number	1803556-98-0 Y
PubChem CID	118308152
ChemSpider	76767388
ChEMBL	ChEMBL3932722
Chemical and physical data
Formula	C19H19F3N8O
Molar mass	432.411 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@]1(CCC[C@@H]1NC(=O)C2=C(C=CC=N2)N3N=CC=N3)NC4=NC=C(N=C4)C(F)(F)F
InChI InChI=1S/C19H19F3N8O/c1-18(29-15-11-24-14(10-25-15)19(20,21)22)6-2-5-13(18)28-17(31)16-12(4-3-7-23-16)30-26-8-9-27-30/h3-4,7-11,13H,2,5-6H2,1H3,(H,25,29)(H,28,31)/t13-,18-/m0/s1 Key:UNZFNWZMBMDMAR-UGSOOPFHSA-N

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