CYP12 family
Group of cytochrome P450 enzymes
From Wikipedia, the free encyclopedia
Cytochrome P450, family 12, also known as CYP12, is a cytochrome P450 family found in insect genome belongs to Mitochondrial clan CYPs, which is located in the inner membrane of mitochondria (IMM).[1][2] The first gene identified in this family is the CYP12A1 from the Musca domestica (house fly), which is involved in insecticide resistance.[3] CYP12A1 protein localization in mitochondria by immunohistochemistry and absolute dependence on mitochondrial electron donors adrenodoxin reductase and adrenodoxin.[3]
Rabbit gene CYP8B1 was named CYP12 at the beginning of its discovery, because it hydroxylated its sterol substrate on the 12 position.[4] However, CYP12 is a family of insect P450s found in mitochondria, so this gene was renamed to CYP8B1.[5]
