Ergotamine/caffeine

Pharmaceutical product From Wikipedia, the free encyclopedia

Ergotamine/caffeine, sold under the brand name Cafergot among others, is a fixed-dose combination medication used for the treatment of migraine. It contains ergotamine, as the tartrate, an alpha adrenergic blocking agent; and caffeine, a cranial vasoconstrictor.[3]

Ergotaminevasoconstrictor, neurotransmitter agonist and antagonist
Caffeinevasoconstrictor, phosphodiesterase inhibitor
Trade namesCafergot, Migergot, others
AHFS/Drugs.comMultum Consumer Information
Quick facts Combination of, Caffeine ...
Ergotamine/caffeine
Combination of
Ergotaminevasoconstrictor, neurotransmitter agonist and antagonist
Caffeinevasoconstrictor, phosphodiesterase inhibitor
Clinical data
Trade namesCafergot, Migergot, others
AHFS/Drugs.comMultum Consumer Information
MedlinePlusa601048
License data
Pregnancy
category
  • AU: C
  • Contraindicated
Routes of
administration		By mouth, rectal
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
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Ergotamine/caffeine is available as a generic medication.

Medical uses

Ergotamine/caffeine is indicated as therapy to abort or prevent vascular headache.[1][2]

Mechanism of action

Ergotamine binds to 5-HT1B and 5-HT1D receptors.[4] This along with binding to other serotonergic and dopaminergic receptors is their presumed mechanism of action in treating migraine.[4][5]

Adverse effects

Because the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, adverse effects due to systemic vasoconstriction can occur. Cold feet or hands, angina pectoris, myocardial infarction,[6] or dizziness are some examples.

It has also been shown to be associated with mitral valve stenosis. [7]

References

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