Cain Creek From Wikipedia, the free encyclopedia River in South Dakota, U.S. Cain Creek is a stream in the U.S. state of South Dakota.[1] Cain Creek has the name of John Cain, an early settler.[2] See also List of rivers of South Dakota References ↑ U.S. Geological Survey Geographic Names Information System: Cain Creek ↑ Federal Writers' Project (1940). South Dakota place-names, v.3. University of South Dakota. p. 19. 44°16′26″N 98°09′47″W / 44.27389°N 98.16306°W / 44.27389; -98.16306 This article related to a river in South Dakota is a stub. You can help Wikipedia by expanding it.vte Related Articles