Calcium-activated potassium channel beta subunit

Protein family From Wikipedia, the free encyclopedia

In molecular biology, the calcium-activated potassium channel beta subunit is a family of proteins comprising the beta subunits of calcium-activated potassium channels.

Quick facts CaKB, Identifiers ...
CaKB
solution structure of the cytoplasmic n-terminus of the bk beta-subunit kcnmb2
Identifiers
SymbolCaKB
PfamPF03185
InterProIPR003930
SCOP21jo6 / SCOPe / SUPFAM
TCDB8.A.14
Available protein structures:
PDB  IPR003930 PF03185 (ECOD; PDBsum)  
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The functional diversity of potassium channels can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. The beta subunit (which is thought to possess 2 transmembrane domains) increases the calcium sensitivity of the BK channel.[1] It does this by enhancing the time spent by the channel in burst-like open states. However, it has little effect on the durations of closed intervals between bursts, or on the numbers of open and closed states entered during gating.[2]

References

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