Sodium calcium edetate
Chemical compound
From Wikipedia, the free encyclopedia
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[1] including both short-term and long-term lead poisoning.[2] Sodium calcium edetate came into medical use in the United States in 1953.[2]
administrationIV, IM
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| Clinical data | |
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| Trade names | Calcium disodium versenate, others |
| Other names | calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate |
| AHFS/Drugs.com | Monograph |
| Routes of administration | IV, IM |
| Drug class | chelating agent |
| ATC code | |
| Identifiers | |
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| CAS Number | |
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| DrugBank | |
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| E number | E385 (antioxidants, ...) |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.482 |
| Chemical and physical data | |
| Formula | C10H12CaN2Na2O8 |
| Molar mass | 374.270 g·mol−1 |
| 3D model (JSmol) | |
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Chelation agent
Sodium calcium edetate is in the chelating agent family of medication.[2] It is a salt of edetate with two sodium atoms and one calcium atom.[3] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[2]
Edetate disodium (Endrate) is a different formulation which does not have the same effects.[2]
Medical use
Sodium calcium edetate's primary use is to treat lead poisoning,[1] for which it is an alternative to succimer.[2] It is given by slow injection into a vein or into a muscle.[1]
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[2] It may also be used to treat plutonium poisoning.[4] It does not appear to be useful for poisoning by tetra-ethyl lead.[2]
Side effects
Common side effects include pain at the site of injection.[2] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[1] Benefits when needed in pregnancy are likely greater than the risks.[2]
History
Sodium calcium edetate came into medical use in the United States in 1953.[2] It is on the World Health Organization's List of Essential Medicines.[5]
