Calpain small subunit 1
Protein found in humans
From Wikipedia, the free encyclopedia
Calpain small subunit 1 (CSS1) is a protein that in humans is encoded by the CAPNS1 gene.[5][6][7]
| CAPNS1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CAPNS1, 30K, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, calpain small subunit 1, Calpain small subunit 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 114170; MGI: 88266; GeneCards: CAPNS1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. The small regulatory subunit consists of an N-terminal domain, containing about 30% glycine residues and a C-terminal Ca-binding domain.[8] Two transcript variants encoding the same protein have been identified for this gene.[7]
Functions
Myotonic dystrophy
This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy.[7]
Biomarker
'Elevated expression of CAPNS1 has been found to be associated with progression of various cancers such as hepatocellular and renal carcinoma. [9]
