Calx-beta motif
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| Calx-beta | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 first ca2+ binding domain of the na,ca-exchanger (ncx1) | |||||||||
| Identifiers | |||||||||
| Symbol | Calx-beta | ||||||||
| Pfam | PF03160 | ||||||||
| InterPro | IPR003644 | ||||||||
| |||||||||
In molecular biology, the calx-beta motif is a protein motif which is present as a tandem repeat in the cytoplasmic domains of Calx sodium-calcium exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet.[1][2]