Calycosin
Chemical compound
From Wikipedia, the free encyclopedia
Calycosin is an O-methylated isoflavone. It can be isolated from Astragalus membranaceus Bge. var. mongholicus[1] and Trifolium pratense L. (red clover).[2]
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| Names | |
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| IUPAC name
3′,7-Dihydroxy-4′-methoxyisoflavone | |
| Systematic IUPAC name
7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one | |
| Other names
7,3′-Dihydroxy-4′-methoxyisoflavone 3′-Hydroxyformononetin | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.222.904 |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C16H12O5 | |
| Molar mass | 284.267 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Biosynthesis
Isoflavone 3′-hydroxylase uses formononetin, NADPH, H+ and O2 to produce calycosin, NADP+ and H2O.
Pharmacology
Calycosin has been shown to possess anti-cancer properties in vitro, and extracts of Astragalus membranaceus have been used to complement chemotherapy regimes in treatment of cancer in China.[3][4][5]
