Capromorelin

Chemical compound From Wikipedia, the free encyclopedia

Capromorelin, sold under the brand names Entyce and Elura, is a medication used for the management of weight loss in cats and dogs.[5][6] Capromorelin is a ghrelin receptor agonist known to increase appetite and weight gain.[2]

Trade namesEntyce, Elura, Eluracat
Other namesCP-424,391
License data
Routes of
administrationBy mouth
Quick facts Clinical data, Trade names ...
Capromorelin
Clinical data
Trade namesEntyce, Elura, Eluracat
Other namesCP-424,391
License data
Routes of
administration		By mouth
ATCvet code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life2.4 hours[4]
Identifiers
  • N-[(2R)-1-[(3aR)-2-methyl-3-oxo-3a-(phenylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-1-oxo-3-(phenylmethoxy)propan-2-yl]-2-amino-2-methylpropanamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H35N5O4
Molar mass505.619 g·mol−1
3D model (JSmol)
  • CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3=NN(C(=O)[C@@]3(C2)CC4=CC=CC=C4)C)N
  • InChI=1S/C28H35N5O4/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20/h4-13,22H,14-19,29H2,1-3H3,(H,30,35)/t22-,28-/m1/s1 checkY
  • Key:KVLLHLWBPNCVNR-SKCUWOTOSA-N checkY
 ☒NcheckY (what is this?)  (verify)
Close

Capromorelin was developed by Pfizer.[7][8]

Capromorelin was approved for veterinary use in the United States in May 2016.[9] It is the second drug approved for the management of weight loss in cats and the first drug approved specifically for the management of weight loss in cats with chronic kidney disease.[2]

Research

Capromorelin functions to stimulate the secretion of growth hormone and as a ghrelin mimetic which causes the body to secrete human growth hormone in a way usually seen at puberty and in young adulthood. Studies have shown the drug to directly raise insulin growth factor 1 (IGF-1) and growth hormone levels.[10]

In a one-year treatment trial (starting 1999) with 395 seniors between 65 and 84 years old, patients who received the drug gained an average of 3 lb (1.4 kg) in lean body mass in the first six months and also were better able to walk in a straight line in a test of balance, strength and coordination. After 12 months, patients receiving capromorelin also had an improved ability to climb stairs; however, the results were not good enough to continue the trial for the second planned year.[11]

As of 2017, capromorelin studies in humans had been discontinued.[12]

Veterinary uses

Capromorelin is indicated for the management of weight loss in cats and dogs.[2]

References

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