Carbamate poisoning
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Carbamate poisoning is poisoning due to exposure to carbamates, which are commonly sold as pesticides around the world. In most respects, it is similar to organophosphate poisoning, though typically less severe or requiring a larger amount of the chemical before symptoms appear.
Similarity to organophosphorus
The array of symptoms typically seen in carbamate poisoning include both muscarinic and nicotinic symptoms.[1] Muscarinic receptor effects include:
- Bradycardia, or reduced heart rate
- Bronchospasm, or tightening of the bronchioles of the lungs
- Miosis, or constriction of the pupils
- Vomiting and abdominal pain
- Diarrhea
- Excessive sweating and salivation
Bronchospasm is a potential life threat, especially when combined with nicotinic effects on the respiratory muscles. Bradycardia can be life-threatening in people with preexisting heart conditions. The combination of sweating, diarrhea, and vomiting can lead to severe dehydration, hypovolemia, and death from hypovolemic shock.[1]
Nicotinic symptoms of carbamate poisoning are caused by weakness, tremors, and fasciculations of muscles across the body. The most notable consequence of this is usually respiratory failure, as the diaphragm and other muscles become too weak to facilitate normal breathing.[1][2]
Symptoms of the central nervous system are possible, but are less frequent and severe than those associated with organophosphate poisoning. Possible symptoms include:[1][3]
- Headache
- Anxiety
- Agitation
- Ataxia
- Seizures, which may progress to a coma
- Apnea caused by disruption of the respiratory center of the brain
Symptoms are overall similar to organophosphate poisoning.[4] However, several notable differences exist: unlike organophosphates, carbamates do not cause covalent bonds to form between the chemical and acetylcholinesterase.[1] This means that organophosphates, but not carbamates, can cause respiratory failure several days or weeks after exposure to the chemical,[2] while also resisting antidote administration.[1] Carbamate poisoning does not cause long-term effects.[3]
Pathogenesis
Most cases of carbamate poisoning are due to exposure to pesticide products containing the chemical. The most common carbamate chemicals in use are captan, ferbam, carbofuran, carbaryl, and aldicarb. Suicidal and homicidal poisonings also occur, but are rare, due to the lower lethality of carbamates in humans compared to other toxic substances.[5]
Like organophosphates, carbamates are toxic because of their ability to bind to and inhibit acetylcholinesterase (AChE). AChE is an enzyme found throughout the human body that breaks down acetylcholine (ACh), a neurotransmitter that causes muscle cells to contract, among other functions. Without AChE, acetylcholine builds up in the neuromuscular junction, eventually saturating the receptors in the junction and causing the muscle cell to contract uncontrollably. In large muscles such as the diaphragm, the muscle cells may use up their energy reserves and be unable to contract any more, resulting in weakness and tremors.[1]