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Carbonic anhydrase 2

Enzyme found in humans From Wikipedia, the free encyclopedia

Carbonic anhydrase II (gene name CA2) is one of sixteen forms of human α carbonic anhydrases.[5] Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. [6] Loss of carbonic anhydrase activity in bones impairs the ability of osteoclasts to promote bone resorption, leading to osteopetrosis.[7]

AliasesCA2, CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, Carbonic anhydrase II, carbonic anhydrase 2
External IDsOMIM: 611492; MGI: 88269; GeneCards: CA2
PDBOrtholog search: PDBe RCSB
Quick facts CA2, Identifiers ...
CA2
Identifiers
AliasesCA2, CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, Carbonic anhydrase II, carbonic anhydrase 2
External IDsOMIM: 611492; MGI: 88269; GeneCards: CA2
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
4.2.1.1↗↗↗↗
4.2.1.69↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001293675
NM_000067

NM_009801
NM_001357334

RefSeq (protein)

NP_000058
NP_001280604

NP_033931
NP_001344263

Location (UCSC)Chr 8: 85.46 – 85.48 MbChr 3: 14.95 – 14.97 Mb
PubMed search[3][4]
Wikidata
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Interactions

Carbonic anhydrase II has been shown to interact with band 3[8][9][10][11] and sodium-hydrogen antiporter 1.[12]

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